Publikasjoner og ansvarsområder
Anti-microbial and cytotoxic 1,6-dihydroxyphenazine-5,10-dioxide (iodinin) produced by Streptosporangium sp. DSM 45942 isolated from the fjord sediment
Phenazine natural products/compounds possess a range of biological activities, including anti-microbial and cytotoxic, making them valuable starting materials for drug development in several therapeutic areas. These compounds are biosynthesized almost exclusively by eubacteria of both terrestrial an...
A new high resolution screening method for study of phenotype stress responses of Saccharomyces cerevisae mutants
Isolation of the biosynthetic gene cluster for TP1161, a novel thiazolyl peptide
Actinobacteria from the Trondheim fjord (Norway): diversity, secondary metabolites, and genes for their biosynthesis
Small-ring macrolactams with acyl side chain: new insights into the biosynthesis and its evolution
BE-14106 and aureoverticillactam represent small-ring macrocyclic lactams with an acyl side chain, which possess anti-tumor activity. We have isolated Streptomyces spp. from marine sediments producing BE-14106 and its close homologue ML-449 with extended acyl side chain. The respective gene clusters...
Chemical modification and biological evaluation of new semisynthetic derivatives of 28,29-Didehydronystatin A1 (S44HP), a genetically engineered antifungal polyene macrolide antibiotic.
Twenty-three new derivatives of the heptaene nystatin analogue 28,29-didehydronystatin A(1) (1) (S44HP) were obtained by chemical modification of C16 carboxyl and amino groups of mycosamine. These derivatives comprised 15 carboxamides, 4 N-alkyl derivatives, 3 N-derivatives containing additional N-l...