Early and reliable detection of diseases is desirable because it dramatically increases the chance for successful treatment. An increasing number of diseases can be detected at an early stage and monitored due to the presence of certain biomarker molecules in the fluids of the human body (blood, sal...

An inherent problem with microfluidic filters is the tendency to clog, especially when applied to cells due to their geometrical complexity, deformability, and tendency to adhere to surfaces. In this work, we handle live algal cells of high complexity without signs of clogging, achieved by exploitin...

Two key issues in the manufacturing of microfluidic devices are to obtain low surface roughness, i.e. in the range of nanometers (to facilitate optical detection and controlled flow through microfluidic networks), and to achieve robust bonding. Here we report that a chemical polishing step, used for...

I det nystartete prosjektet EXIT (EXosomes Isolation Tool) skal SINTEF, som en del av en flerfaglig gruppe, utvikle et miniatyrisert analyseverktøy for å undersøke eksosomer i prøver fra pasienter med Alzheimers sykdom. Eksosomer «bærer» ulike molekyler som protein...

We present a detailed experimental study of a hydrodynamic filtration microchip and show how chip performance can be tuned and clogging avoided by adjusting the flow rates. We demonstrate concentration and separation of microspheres at throughputs as high as 29  ml/min and with 96% pureness. Results...

Two key issues in the manufacturing of microfluidic devices are to obtain low surface roughness, i.e. in the range of nanometers (to facilitate optical detection and controlled flow through microfluidic networks), and to achieve robust bonding. Here we report that a chemical polishing step, used for...

A new rapid prototyping method is reported. It is based on injection molding with inexpensive mold inserts, 3D-printed in durable polymer-based materials. The method allows for manufacturing of microfluidics in common thermoplastics materials at a lower cost and with shorter lead-times compared to i...