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Separation and Concentration without Clogging Using a High-Throughput Tunable Filter

Abstract

We present a detailed experimental study of a hydrodynamic filtration microchip and show how chip performance can be tuned and clogging avoided by adjusting the flow rates. We demonstrate concentration and separation of microspheres at throughputs as high as 29  ml/min and with 96% pureness. Results of streakline visualizations show that the thickness of a tunable filtration layer dictates the cutoff size and that two different concentration mechanisms exist. Particles larger than pores are concentrated by low-velocity rolling over the filtration pillars, while particles smaller than pores are concentrated by lateral drift across the filtration layer. Results of microscopic particle image velocimetry and particle-tracking velocimetry show that the degree of lateral migration can be quantified by the slip velocity between the particle and the surrounding fluid. Finally, by utilizing differences in inertia and separation mode, we demonstrate size-based separation of particles in a mixture

Category

Academic article

Client

  • Research Council of Norway (RCN) / 232148

Language

English

Author(s)

Affiliation

  • University of Oslo
  • Trilobite Microsystems AS
  • SINTEF Digital / Microsystems and Nanotechnology

Year

2018

Published in

Physical Review Applied

ISSN

2331-7019

Volume

9

Issue

5

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