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Oxidative DNA damage is recognized by 8-oxoguanine (8-oxoG) DNA glycosylase 1 (OGG1), which excises 8-oxoG, leaving a substrate for apurinic endonuclease 1 (APE1) and initiating repair. Here, we describe a small molecule (TH10785) that interacts with the phenylalanine-319 and glycine-42 amino acids...

Hovedutfordringen for ZEN pilotområdet Ydalir er å sikre en riktig tilnærming til målet om reduksjon av klimagassutslipp slik at de totalt sett oppnår en balanse mellom samfunnshensyn, miljø og økonomi, for både utbygger og bruker. Denne rapporten ser nærmere på disse parameterne og ser på hvor mye...

Headlines in December 2024 proclaimed the “collapse” and “failure” of United Nations plastics treaty negotiations in Busan, South Korea. This is, however, an overly simplistic and pessimistic portrayal. Progress on less contentious issues was made, and the meeting was adjourned with a commitment to...

Planning and building for future disassembly and the reuse of materials have been identified as promising design strategies for the implementation of circular economy principles in the construction sector. These strategies are expected to contribute to reducing material related greenhouse gas (GHG...

Persons with autism spectrum disorder (ASD) and/or intellectual disability (ID) have difficulties in planning, organising and coping with change, which impedes the learning of daily living skills (DLSs), social participation and self-management across different environmental settings. Assistive...

Hovedutfordringen for ZEN pilotområdet Ydalir er å sikre en riktig tilnærming til målet om reduksjon av klimagassutslipp slik at de totalt sett oppnår en balanse mellom samfunnshensyn, miljø og økonomi, for både utbygger og bruker. Denne rapporten ser nærmere på disse parameterne og ser på hvor mye...

Greenland extends from 60° to 83° N, with 80% of its land mass covered by the Greenland Ice Sheet (GrIS). This extensive latitudinal gradient is associated with concomitant environmental gradients that impact the biogeochemical properties of its coastal waters. Although the Greenland fjords have...

Materials science is at the crossroad between fundamental and applied sciences. Whether enabling clean energy, next-generation computing, or advanced manufacturing, it shapes the tools we use and the systems we build. As our societies undergo rapid digital, environmental, and technological...

The International Council for the Exploration of the Sea (ICES) has included human dimensions in its science and advice selectively and implicitly throughout its history, but formal recognition of social science and humanities as a core research theme only emerged in 2015. This paper examines the...