Publikasjoner og ansvarsområder
Effect of Ultrasound on the Vasculature and Extravasation of Nanoscale Particles Imaged in Real Time
Ultrasound and microbubbles have been found to improve the delivery of drugs and nanoparticles to tumor tissue. To obtain new knowledge on the influence of vascular parameters on extravasation and to elucidate the effect of acoustic pressure on extravasation and penetration of nanoscale particles in...
Exploration of mechanism leading to plaque instability in a rabbit atherosclerotic model. Preliminary data.
Background: Atherosclerosis is a lipoprotein-driven disease that leads to plaque formation at specific sites of the arterial tree through intimal inflammation, fibrosis, necrosis, and calcification. Sometimes such plaques may suddenly cause life-threatening coronary thrombosis clinically described a...
Sonoporation enhances delivery of nanomedicine for improved cancer treatment
Extravasation and distribution of nanoparticles and 2MDa dextran in tumor imaged by multiphoton microscopy during ultrasound sonication.
In-vitro contrast agent detection combining pulse inversion and SURF imaging
Microbubbles as an ultrasound contrast agent have great diagnostic value, and can be used to visualize the vascularization in a variety of organs, e.g. imaging the neo-angiogenesis in tumors. Pulse inversion (PI) is a common method for detection of these bubbles, implemented in many ultrasound scann...