Publikasjoner og ansvarsområder
Simple and robust intravital microscopy procedures in hybrid TIE2GFP-BALB/c transgenic mice
Purpose The endeavor of deciphering intricate phenomena within the field of molecular medicine dictates the necessity to investigate tumor/disease microenvironment real-time on cellular level. We, hereby, design simple and robust intravital microscopy strategies, which can be used to elucidate cellu...
Blood brain barrier opening and Therapeutic Effect of Free and Nanoencapsulated Cabazitaxel in an Invasive Patient-Derived Glioblastoma Model
From Drug Discovery to Preclinical Studies: SINTEFs Nanoparticle-Based Technologies for Cancer Treatment
Therapeutic effect of cabazitaxel and blood-brain barrier opening in a patient-derived glioblastoma model
Effect of ultrasound on the vasculature and extravasation of nanoscale particles imaged in real time
Effect of Ultrasound on the Vasculature and Extravasation of Nanoscale Particles Imaged in Real Time
Ultrasound and microbubbles have been found to improve the delivery of drugs and nanoparticles to tumor tissue. To obtain new knowledge on the influence of vascular parameters on extravasation and to elucidate the effect of acoustic pressure on extravasation and penetration of nanoscale particles in...
3DLife: Validating new high-throughput methods for 3D cell culture screening
The Effect of Sonication on Extravasation and Distribution of Nanoparticles and Dextrans in Tumor Tissue Imaged by Multiphoton Microscopy
Ultrasound (US)and systemic administration of microbubbles (MBs)have been shown to improve the delivery of drugs and nanoparticles (NPs)to tumor tissue. A better understanding of the mechanisms is crucial for effective delivery of NPs and drugs. To elucidate the kinetics of extravasation events, and...