Publikasjoner og ansvarsområder
Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects
Thermal proteome profiling identifies oxidative-dependent inhibition of the transcription of major oncogenes as a new therapeutic mechanism for select anticancer compounds
Targeting OGG1 arrests cancer cell proliferation by inducing replication stress
Abstract Altered oncogene expression in cancer cells causes loss of redox homeostasis resulting in oxidative DNA damage, e.g. 8-oxoguanine (8-oxoG), repaired by base excision repair (BER). PARP1 coordinates BER and relies on the upstream 8-oxoguanine-DNA glycosylase (OGG1) to recognise and excise...
Bridging gaps in the immunotherapeutic research pipeline
Immunotherapy is quickly changing the current cancer treatment paradigm and is becoming the future of cancer medicine. Although the field is promising, successful translation of basic research findings from cancer biology, molecular biology and immunology to patient treatment and clinical trials...