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Kinetic Study of Butanol Production from Mixtures of Glucose and Xylose and Investigation of Different Pre-growth Strategies

Kinetic Study of Butanol Production from Mixtures of Glucose and Xylose and Investigation of Different Pre-growth Strategies

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Tidsskriftspublikasjon
Sammendrag
This study proposes a dynamic model that describes key characteristics of fermentative butanol production from glucose and xylose mixtures. The model has 12 parameters and incorporates noncompetitive inhibitory interaction between sugars as well as inhibitions due to high substrate and butanol concentrations. Different pre-growth strategies to achieve co-utilization of sugars were explored together with their effects on fermentation kinetics. Mixed sugar fermentation by the cultures pre-grown on a mixture of glucose and xylose showed a higher endurance to inhibition, a 2-fold increase in butanol production and a 1.5-fold increase in total sugar consumption compared to cultures pre-grown on xylose only. The average squared correlation coefficients (r2) between experimental observations and model predictions were 0.917 and 0.926 for fermentations done by the cultures pre-grown on xylose only, and pre-grown on a mixture of glucose and xylose, respectively. Sensitivity analysis on the model parameters revealed that the growth parameters were the most critical. The proposed model can serve as a basis for modeling of microbial butanol production from lignocellulosic biomass and be applied to other substrates and microorganisms. © 2019(32 refs)
Oppdragsgiver
  • Norges forskningsråd / 246821
Språk
Engelsk
Forfatter(e)
Institusjon(er)
  • SINTEF Energi AS / Termisk energi
  • Norges teknisk-naturvitenskapelige universitet
  • SINTEF Industri / Prosessteknologi
  • SINTEF Industri / Bioteknologi og nanomedisin
År
2019
Publisert i
Biochemical engineering journal
ISSN
1369-703X
Årgang
147
Side(r)
110 - 117