To main content

Administration of spruce bark (Picea abies) extracts in young lambs exhibits anticoccidial efects but reduces milk intake and body weight gain

Abstract

Background
Eimeria spp. are widespread apicomplexan parasites known to cause coccidiosis in livestock, resulting in reduced animal welfare and productivity, particularly in sheep. The treatment options are limited, and there is an emerging development of resistance against registered pharmaceuticals. Spruce bark is rich in plant secondary metabolites (PSM), such as condensed tannins, which are bioactive compounds previously shown to have antiparasitic activity. Here, we examined the anticoccidial properties of bark extract of Norway spruce (Picea abies) against a field isolate of ovine Eimeria spp. by treating Eimeria-infected pre-ruminant lambs with water-extracted bark daily for 12 days. We hypothesised that the bark extract would reduce the faecal oocyst excretion and, consequently, the severity of diarrhoea.

Results
Oral administration of spruce bark extract significantly reduced the excretion of Eimeria oocysts in milk-fed lambs post treatment till the end of the trial 22 days post infection. This difference in oocyst excretion between the treated and the untreated infected animals increased with time.

Compared to the untreated and the sham-infected control group, the group treated with bark extract had softer faeces and reduced milk intake during the treatment period. After discontinuing the treatment, the treated animals got a more solid and formed faeces compared to that of the untreated control group, and the milk intake increased to the level of the sham-infected, untreated control group. The bark extract treated animals had a lower body weight and a lower mean daily body weight gain throughout the whole duration of the experiment.

Conclusions
Bark extract from Norway spruce showed marked anticoccidial properties by reducing the faecal oocyst count and associated diarrhoea in young lambs. Simultaneously we experienced detrimental effects of the treatment, displayed as reduced feed intake and daily body weight gain. Therefore, we suggest conducting similar studies with lower bark extract dosage to explore the possibilities of a better trade-off to reduce the negative impact while maintaining the antiparasitic effect. Keywords: Coccidia, Coccidiocide, Eimeria, Industrial by-products, Sheep

Category

Academic article

Client

  • EC/H2020 / 774340
  • Research Council of Norway (RCN) / 268264

Language

English

Author(s)

  • Berit Marie Blomstrand
  • Heidi L Enemark
  • Håvard Steinshamn
  • Inga Marie Aasen
  • Juni Rosann E. Johanssen
  • Spiridoula Athanasiadou
  • Stig Milan Thamsborg
  • Kristin Sørheim

Affiliation

  • Norwegian Centre for Organic Agriculture
  • Norwegian Veterinary Institute
  • Norwegian Institute of Bioeconomy Research
  • SINTEF Industry / Biotechnology and Nanomedicine
  • Scotland's Rural College
  • University of Copenhagen

Year

2022

Published in

Acta Veterinaria Scandinavica (AVS)

ISSN

0044-605X

Publisher

BioMed Central (BMC)

Volume

64

Issue

1

View this publication at Cristin