Commercial aquaponics systems remain a challenge independent of the country, fish, plant species, or system design type. Most aquaponics systems are made by hobbyists, with aquaponics not being the main source of income. As such, scholars and practitioners have long debated the real profitability of aquaponics systems. With the growth of the aquaponics industry and commercial businesses, sustainable economic viability is necessary. Recently, considerable literature has been published around the theme of aquaponics systems design but there is a gap in the literature regarding the business aspect of this. Moreover, only by acquiring the enterprise knowledge of planning a business case, obtaining funds, and running and maintaining a business will this industry be able to grow. This paper intends to create a directory of possible considerations to plan for a viable commercial aquaponics system by uniting already established business frameworks and adapting them to the aquaponics industry. This framework proposes a guide to evaluate the economic feasibility of the enterprise depending on the revenues, costs and investments needed for the chosen system within its operations, market, and environment.