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Glioblastoma Surgery Imaging—Reporting and Data System: Standardized Reporting of Tumor Volume, Location, and Resectability Based on Automated Segmentations

Abstract

Treatment decisions for patients with presumed glioblastoma are based on tumor characteristics available from a preoperative MR scan. Tumor characteristics, including volume, location, and resectability, are often estimated or manually delineated. This process is time consuming and subjective. Hence, comparison across cohorts, trials, or registries are subject to assessment bias. In this study, we propose a standardized Glioblastoma Surgery Imaging Reporting and Data System (GSI-RADS) based on an automated method of tumor segmentation that provides standard reports on tumor features that are potentially relevant for glioblastoma surgery. As clinical validation, we determine the agreement in extracted tumor features between the automated method and the current standard of manual segmentations from routine clinical MR scans before treatment. In an observational consecutive cohort of 1596 adult patients with a first time surgery of a glioblastoma from 13 institutions, we segmented gadolinium-enhanced tumor parts both by a human rater and by an automated algorithm. Tumor features were extracted from segmentations of both methods and compared to assess differences, concordance, and equivalence. The laterality, contralateral infiltration, and the laterality indices were in excellent agreement. The native and normalized tumor volumes had excellent agreement, consistency, and equivalence. Multifocality, but not the number of foci, had good agreement and equivalence. The location profiles of cortical and subcortical structures were in excellent agreement. The expected residual tumor volumes and resectability indices had excellent agreement, consistency, and equivalence. Tumor probability maps were in good agreement. In conclusion, automated segmentations are in excellent agreement with manual segmentations and practically equivalent regarding tumor features that are potentially relevant for neurosurgical purposes. Standard GSI-RADS reports can be generated by open access software.

Category

Academic article

Language

English

Author(s)

  • Ivar Kommers
  • David Bouget
  • André Pedersen
  • Roelant Eijgelaar
  • Hilko Ardon
  • Frederik Barkhof
  • Lorenzo Bello
  • Mitchel S. Berger
  • Marco Conti Nibali
  • Julia Furtner
  • Even Hovig Fyllingen
  • Shawn Hervey-Jumper
  • Albert J. S. Idema
  • Barbara Kiesel
  • Alfred Kloet
  • Emmanuel Mandonnet
  • Domenique M. J. Müller
  • Pierre Robe
  • Marco Rossi
  • Lisa Millgård Sagberg
  • Tommaso Sciortino
  • Wimar A. van den Brink
  • Michiel Wagemakers
  • Georg Widhalm
  • Marnix G. Witte
  • Aeilko H. Zwinderman
  • Ingerid Reinertsen
  • Ole Solheim
  • Philip C. De Witt Hamer

Affiliation

  • Vrije Universiteit Amsterdam Medical Center
  • SINTEF Digital / Health Research
  • Netherlands
  • University College London
  • University of Milan
  • USA
  • Switzerland
  • Norwegian University of Science and Technology
  • St. Olavs Hospital, Trondheim University Hospital
  • Austria
  • Haaglanden Medical Center
  • France
  • University Medical Center Utrecht
  • University Medical Center Groningen
  • Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital

Year

2021

Published in

Cancers

ISSN

2072-6694

Publisher

MDPI

Volume

13

Issue

12

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