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Navigated retrograde endoscopic myotomy (REM) for the treatment of therapy-resistant achalasia

Navigated retrograde endoscopic myotomy (REM) for the treatment of therapy-resistant achalasia

Category
Academic article
Abstract
Background

In achalasia, muscle spasm may involve the proximal esophagus. When the muscle spasm is located in the proximal esophagus, conventional per oral endoscopic myotomy (POEM) may not be sufficient to relieve symptoms. In this paper, we describe retrograde endoscopic myotomy (REM) as a novel approach to perform myotomy of the proximal esophagus, with the application of a navigation tool for anatomical guidance during REM. We aim to evaluate the feasibility and safety of REM and usefulness of the navigation during REM.


Method

A 42‐year‐old male with type III achalasia who was treated with laparoscopic myotomy with fundoplication, multiple pneumatic balloon dilations, Botox injections and anterior POEM of the middle and distal esophagus without symptomatic effect. Repeated high‐resolution‐ manometry (HRM) revealed occluding contractions of high amplitude around and above the aortic arch. A probe‐based real‐time electromagnetic navigation platform was used to facilitate real‐time anatomical orientation and to evaluate myotomy position and length during REM.


Results

The navigation system aided in identifying the major structures of the mediastinum, and position and length of the myotomy. Twelve weeks after REM, the Eckardt score fell from seven at baseline seven to two. We also observed improvement with reduction of the pressure at the level of previous spasms in the proximal esophagus from 124 mmHg to 8 mmHg on HRM.


Conclusion

REM makes the proximal esophagus accessible for endoscopic myotomy. Potential indication for REM is motility disorders in the proximal esophagus and therapy failure after POEM.

Language
English
Author(s)
Affiliation
  • University of Bergen
  • Bergen Hospital Trust - Haukeland University Hospital
  • St. Olavs Hospital, Trondheim University Hospital
  • SINTEF Digital / Health Research
Year
Published in
Neurogastroenterology and Motility
ISSN
1350-1925
Volume
30
Issue
4