Industry is facing the fourth revolution being forced to move from horizontal and vertical activity-sliced flows to instant data- and situation-driven communication and collaboration. To serve new markets and customers industry must deliver sustainable products and services to stay competitive, and new knowledge assets, design methodologies and ICT capabilities must be designed and implemented. Companies must be able to simultaneously participate in many diverse networks performing R&D in parallel with learning and innovation, business operations and customer service delivery. Novel digital innovations are driving demands for sustainable life-cycle capabilities. To meet these all actors involved must embrace new knowledge concepts enabling agile approaches to emergent solutions, and building open platforms to enhance human communication and collaboration. Agile approaches to holistic design depend on sustainable knowledge bases, built as active knowledge architectures. Prototypes have been built for life-cycle support, and best-practice reuse. Industries must be able to adapt data, knowledge, capabilities and services to new customers, and take care of environmental footprints and human preferences. Present horizontal and vertical flows are replaced by data- and situation-driven collaboration supported by effective knowledge sharing.