Senior Research Scientist
Senior Research Scientist
Publications and responsibilities
Effect of ultrasound on the vasculature and extravasation of nanoscale particles imaged in real time
Exploration of mechanism leading to plaque instability in a rabbit atherosclerotic model. Preliminary data.
Background: Atherosclerosis is a lipoprotein-driven disease that leads to plaque formation at specific sites of the arterial tree through intimal inflammation, fibrosis, necrosis, and calcification. Sometimes such plaques may suddenly cause life-threatening coronary thrombosis clinically described a...
The Effect of Sonication on Extravasation and Distribution of Nanoparticles and Dextrans in Tumor Tissue Imaged by Multiphoton Microscopy
Ultrasound (US)and systemic administration of microbubbles (MBs)have been shown to improve the delivery of drugs and nanoparticles (NPs)to tumor tissue. A better understanding of the mechanisms is crucial for effective delivery of NPs and drugs. To elucidate the kinetics of extravasation events, and...
Sonoporation enhances delivery of nanomedicine for improved cancer treatment
Extravasation and distribution of nanoparticles and 2MDa dextran in tumor imaged by multiphoton microscopy during ultrasound sonication.
Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma of a metastatic brain tumour model
The treatment of brain diseases is hindered by the blood-brain barrier (BBB) preventing most drugs from entering the brain. Focused ultrasound (FUS) with microbubbles can open the BBB safely and reversibly. Systemic drug injection might induce toxicity, but encapsulation into nanoparticles reduces a...
In-vitro contrast agent detection combining pulse inversion and SURF imaging
Microbubbles as an ultrasound contrast agent have great diagnostic value, and can be used to visualize the vascularization in a variety of organs, e.g. imaging the neo-angiogenesis in tumors. Pulse inversion (PI) is a common method for detection of these bubbles, implemented in many ultrasound scann...
Ultrasound Improves the Delivery and Therapeutic Effect of Nanoparticle-Stabilized Microbubbles in Breast Cancer Xenografts
Primary Porcine Brain Endothelial Cells as In Vitro Model to Study Effects of Ultrasound and Microbubbles on Blood-Brain Barrier Function
Focused ultrasound (FUS) in the presence of microbubbles transiently and reversibly opens the blood-brain barrier (BBB) in rodents and humans, thereby providing a time window for increased drug delivery into brain tissue. To get insight into the underlying mechanisms that govern ultrasound (US)-medi...