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Advanced ex vivo analyses and multi-frequency ultrasound technology for improved evaluation and diagnosis of coronary plaque.

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Atherosclerosis is considered a multifactorial disease with risk factors ranging from high-fat diet, hypertension, smoking, diabetes, to genetic susceptibility and other factors. Classic statin treatment has led to significant reduction of clinical events, but considerable residual risk of cardiovascular-related mortality still remains.

By analyzing blood and plaque samples from both patient and animal models, the XploreCAD project will identify potential biomarkers of coronary artery disease that will be used in combination with novel ultrasound technology for improved imaging of coronary plaque.

Expected results will lead to better understanding of the mechanisms related to plaque progression and plaque instability, and an improved imaging technique for plaque diagnosis.

International partners

Felicia Anthoe, Institute of Cellular Biology and Pathology, Romania
Mathieu Legros, Vermon, France
Kenneth Caidahl, Karolinska University Hospital, Sweden (Associated partner)


European Research Area Network on Cardiovascular Diseases – ERA-CVD

National research agencies involved:
The Research Council of Norway (RCN)
Agence Nationale de la Recherche (ANR)
Autoritatea Nationala pentru Cercetare Stiintifica si Inovare

Participants at SINTEF

Sigrid Berg and Jørgen Avdal

Key Factors

Project duration

2018 - 2018

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