Ultrasound and microbubbles have been found to improve the delivery of drugs and nanoparticles to tumor tissue. To obtain new knowledge on the influence of vascular parameters on extravasation and to elucidate the effect of acoustic pressure on extravasation and penetration of nanoscale particles in...

Background: Atherosclerosis is a lipoprotein-driven disease that leads to plaque formation at specific sites of the arterial tree through intimal inflammation, fibrosis, necrosis, and calcification. Sometimes such plaques may suddenly cause life-threatening coronary thrombosis clinically described a...

Ultrasound (US)and systemic administration of microbubbles (MBs)have been shown to improve the delivery of drugs and nanoparticles (NPs)to tumor tissue. A better understanding of the mechanisms is crucial for effective delivery of NPs and drugs. To elucidate the kinetics of extravasation events, and...

The treatment of brain diseases is hindered by the blood-brain barrier (BBB) preventing most drugs from entering the brain. Focused ultrasound (FUS) with microbubbles can open the BBB safely and reversibly. Systemic drug injection might induce toxicity, but encapsulation into nanoparticles reduces a...

Microbubbles as an ultrasound contrast agent have great diagnostic value, and can be used to visualize the vascularization in a variety of organs, e.g. imaging the neo-angiogenesis in tumors. Pulse inversion (PI) is a common method for detection of these bubbles, implemented in many ultrasound scann...