To main content

Formation of neural networks with structural and functional features consistent with small-world network topology on surface-grafted polymer particles

Formation of neural networks with structural and functional features consistent with small-world network topology on surface-grafted polymer particles

Category
Journal publication
Abstract
In vitro electrophysiological investigation of neural activity at a network level holds tremendous potential for elucidating underlying features of brain function (and dysfunction). In standard neural network modelling systems, however, the fundamental three-dimensional (3D) character of the brain is a largely disregarded feature. This widely applied neuroscientific strategy affects several aspects of the structure–function relationships of the resulting networks, altering network connectivity and topology, ultimately reducing the translatability of the results obtained. As these model systems increase in popularity, it becomes imperative that they capture, as accurately as possible, fundamental features of neural networks in the brain, such as small-worldness. In this report, we combine in vitro neural cell culture with a biologically compatible scaffolding substrate, surface-grafted polymer particles (PPs), to develop neural networks with 3D topology. Furthermore, we investigate their electrophysiological network activity through the use of 3D multielectrode arrays. The resulting neural network activity shows emergent behaviour consistent with maturing neural networks capable of performing computations, i.e. activity patterns suggestive of both information segregation (desynchronized single spikes and local bursts) and information integration (network spikes). Importantly, we demonstrate that the resulting PP-structured neural networks show both structural and functional features consistent with small-world network topology.
Client
  • Norges forskningsråd / 245963 (NorFab)
Language
English
Author(s)
Affiliation
  • Norwegian University of Science and Technology
  • SINTEF Industry / Biotechnology and Nanomedicine
  • Osaka Prefecture University
  • St. Olavs Hospital, Trondheim University Hospital
  • Sweden
Year
2019
Published in
Royal Society Open Science
ISSN
2054-5703
Publisher
The Royal Society Publishing
Volume
6
Issue
10