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Influence of polymer coating on release of L-dopa from core-shell Fe@Au nanoparticle systems

Influence of polymer coating on release of L-dopa from core-shell Fe@Au nanoparticle systems

Category
Journal publication
Abstract
We report on the effect of different stimuli-responsive polymer shells on Fe@Au core-shell nanoparticles (NPs) with respect to thermoresponse as well as loading and release characteristics. The hybrid NP systems were investigated using a wide array of characterization techniques including dynamic light scattering, electrophoretic mobility, UV-visible spectroscopy, and scanning transmission electron microscopy. Three different polymeric shells were selected for loading and release of l-dopa: thiolated polyethylene glycol (PEG), poly(N-isopropylacrylamide-co-acrylic acid) (PNIPAAM_AAc) microgel crosslinked with N,N′-methylenebis(acrylamide) (BIS), and finally concomitant PEG and PNIPAAM_AAc microgel (Fe@Au_PEG_Microgel). All three shells were found to exhibit high loading (∼10%) and encapsulation efficiencies up to 100 μg l-dopa/mg. Although the loading efficiencies are comparable for the three systems, Fe@Au_PEG_Microgel has the highest release (87%) at elevated temperature and acidic conditions. The attenuated release from the PEG-based systems can be attributed to stronger dipole-dipole interactions between the carboxyl group of PEG and the amino group of l-dopa.
Client
  • Norges forskningsråd / 245963
Language
English
Author(s)
  • Bandyopadhyay Sulalit
  • Alvi Muhammad Awais Ashfaq
  • Sharma Anuvansh
  • Zhu Kaizheng
  • Kjøniksen Anna-Lena
  • Nyström Bo
  • Glomm Wilhelm
Affiliation
  • Norwegian University of Science and Technology
  • Norwegian University of Science and Technology
  • University of Oslo
  • Østfold University College
  • SINTEF Industry / Biotechnology and Nanomedicine
Year
2017
Published in
Colloid and Polymer Science
ISSN
0303-402X
Volume
295
Issue
2
Page(s)
391 - 402