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Cardiovascular disease in patients with genotyped familial hypercholesterolemia in Norway during 1994-2009, a registry study

Cardiovascular disease in patients with genotyped familial hypercholesterolemia in Norway during 1994-2009, a registry study

Category
Journal publication
Abstract
BACKGROUND: Familial hypercholesterolaemia increases the risk for cardiovascular disease. The primary aim of the present study was to describe sex differences in incidence and prevalence of cardiovascular disease leading to hospitalisation in a complete cohort of genotyped familial hypercholesterolaemia patients. DESIGN AND METHODS: In this registry study data on 5538 patients with verified genotyped familial hypercholesterolaemia were linked to data on all Norwegian cardiovascular disease hospitalisations, and hospitalisations due to pre-eclampsia/eclampsia, congenital heart defects and diabetes. RESULTS: During 1994-2009 a total of 1411 of familial hypercholesterolaemia patients were hospitalised, and ischaemic heart disease was reported in 90% of them. Mean (SD) age at first hospitalisation and first re-hospitalisation was 45.1 (16.5) and 47.6 (16.3) years, respectively, with no sex differences (P = 0.66 and P = 0.93, respectively). More men (26.9%) than women (24.1%) with familial hypercholesterolaemia were hospitalised (P = 0.02). The median (25th-75th percentile) number of hospital admissions was four (two to seven) per familial hypercholesterolaemia patient, with no sex differences (P = 0.87). Despite having familial hypercholesterolaemia at the time of hospitalisation, the diagnosis of familial hypercholesterolaemia was registered in only 45.7% of the patients at discharge. CONCLUSION: Most cardiovascular disease hospitalisations were due to ischaemic heart disease. Familial hypercholesterolaemia patients were first time hospitalised at age 45.1 years, with no significant sex differences in age, which are important novel findings. The awareness and registration of the familial hypercholesterolaemia diagnosis during the hospital stays were disturbingly low.
Language
English
Author(s)
  • Mundal Liv
  • Veierød Marit Bragelien
  • Halvorsen Thomas
  • Holven Kirsten Bjørklund
  • Ose Leiv
  • Iversen Per Ole
  • Tell Grethe Seppola
  • Leren Trond Paul
  • Retterstøl Kjetil
Affiliation
  • Oslo University Hospital
  • University of Oslo
  • University of Oslo
  • SINTEF Digital / Health Research
  • University of Oslo
  • Oslo University Hospital
  • University of Oslo
  • Oslo University Hospital
  • University of Bergen
  • Norwegian Institute of Public Health
  • Oslo University Hospital
Year
2016
Published in
European Journal of Preventive Cardiology
ISSN
2047-4873
Volume
23
Issue
18
Page(s)
1962 - 1969