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The use of flow chemistry for two-phase dibromocyclopropanation of alkenes

The use of flow chemistry for two-phase dibromocyclopropanation of alkenes

Category
Journal publication
Abstract
Conventional batch dibromocyclopropanations by reaction of bromoform and alkenes under phase-transfer conditions require strong base (50% NaOH (aq)), vigorous stirring, and often long reaction times. Using flow chemistry in a microreactor, the reactions were found to be smooth, rapid, and high-yielding under ambient conditions when 40% (w/w) NaOH was used as the base. The reaction has been tested with a representative selection of alkenes, displaying a variety of structural features.
Language
English
Author(s)
Affiliation
  • Norwegian University of Life Sciences
  • SINTEF Industry / Process Technology
Year
2015
Published in
Journal of Flow Chemistry
ISSN
2062-249X
Publisher
Ungarn, Akadémiai Kiadó
Volume
5
Issue
2
Page(s)
69 - 73