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Learning deep abdominal CT registration through adaptive loss weighting and synthetic data generation

Abstract

Purpose
This study aims to explore training strategies to improve convolutional neural network-based image-to-image deformable registration for abdominal imaging.

Methods
Different training strategies, loss functions, and transfer learning schemes were considered. Furthermore, an augmentation layer which generates artificial training image pairs on-the-fly was proposed, in addition to a loss layer that enables dynamic loss weighting.

Results
Guiding registration using segmentations in the training step proved beneficial for deep-learning-based image registration. Finetuning the pretrained model from the brain MRI dataset to the abdominal CT dataset further improved performance on the latter application, removing the need for a large dataset to yield satisfactory performance. Dynamic loss weighting also marginally improved performance, all without impacting inference runtime.

Conclusion
Using simple concepts, we improved the performance of a commonly used deep image registration architecture, VoxelMorph. In future work, our framework, DDMR, should be validated on different datasets to further assess its value.
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Category

Academic article

Language

English

Author(s)

Affiliation

  • SINTEF Digital / Health Research
  • St. Olavs Hospital, Trondheim University Hospital
  • Norwegian University of Science and Technology
  • Oslo University Hospital

Year

2023

Published in

PLOS ONE

Volume

18

Issue

2

View this publication at Norwegian Research Information Repository