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Is the anatomical distribution of low-grade gliomas linked to regions of gliogenesis?

Abstract

Introduction
According to the stem cell theory, two neurogenic niches in the adult human brain may harbor cells that initiate the formation of gliomas: The larger subventricular zone (SVZ) and the subgranular zone (SGZ) in the hippocampus. We wanted to explore whether defining molecular markers in low-grade gliomas (LGG; WHO grade II) are related to distance to the neurogenic niches.

Methods
Patients treated at two Norwegian university hospitals with population-based referral were included. Eligible patients had histopathological verified supratentorial low-grade glioma. IDH mutational status and 1p19q co-deletion status was retrospectively assessed. 159 patients were included, and semi-automatic tumor segmentation was done from pre-treatment T2-weighted (T2W) or Fluid-Attenuated Inversion Recovery (FLAIR) images. 3D maps showing the anatomical distribution of the tumors were then created for each of the three molecular subtypes (IDH mutated/1p19q co-deleted, IDH mutated and IDH wild-type). Both distance from tumor center and tumor border to the neurogenic niches were recorded.

Results
In this population-based cohort of previously untreated low-grade gliomas, we found that low-grade gliomas are more often found closer to the SVZ than the SGZ, but IDH wild-type tumors are more often found near SGZ.

Conclusion
Our study suggests that the stem cell origin of IDH wild-type and IDH mutated low-grade gliomas may be different.
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Category

Academic article

Language

English

Author(s)

  • Anne Jarstein Skjulsvik
  • Hans Kristian Bø
  • Asgeir S Jakola
  • Erik Magnus Berntsen
  • Lars Eirik Bø
  • Ingerid Reinertsen
  • Kristin Smistad Myrmel
  • Kristin Sjåvik
  • Kristin Åberg
  • Thomas Berg
  • Yan Dai Hong
  • Roar Kloster
  • Sverre Helge Torp
  • Ole Solheim

Affiliation

  • SINTEF Digital / Health Research
  • Sahlgrenska Academy, University of Gothenburg
  • Sahlgrenska University Hospital
  • University Hospital of North Norway
  • Nordland Hospital Trust
  • St. Olavs Hospital, Trondheim University Hospital
  • Norwegian University of Science and Technology

Year

2020

Published in

Journal of Neuro-Oncology

ISSN

0167-594X

Volume

147

Page(s)

147 - 157

View this publication at Norwegian Research Information Repository