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Two-phase dibromocyclopropanation of unsaturated alcohols using flow chemistry

Abstract

Dibromocyclopropanations are conventionally done by addition of dibromocarbene to alkenes under phase-transfer conditions in batch reactions using a strong base (50% NaOH (aq)), vigorous stirring and long reaction times. We have shown that cyclopropanation of unsaturated alcohols can be done under ambient conditions using continuous flow chemistry with 40% (w/w) NaOH (aq) as the base. The reactions were generally rapid; the yields were comparable to yields reported in the literature for the conventional batch reaction
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Category

Academic article

Language

English

Author(s)

  • Runa Berg Østby
  • Terje Didriksen
  • Simen Gjelseth Antonsen
  • Steinar Sollien Nicolaisen
  • Yngve H. Stenstrøm

Affiliation

  • SINTEF Industry / Process Technology
  • Norwegian University of Life Sciences
  • Østfold University College

Date

19.05.2020

Year

2020

Published in

Molecules

ISSN

1431-5157

Volume

25

Issue

10

View this publication at Norwegian Research Information Repository