The isolation of graphene has resulted in an increase in the interest in two-dimensional materials. These materials can be selected based on their electronic structure, ranging from semiconductor to insulator. Moreover, the vertical stacking of these materials into heterostructures results in new properties and applications leading to a plethora of opportunities. In this talk, I will present methods to assemble Van der Waals heterostructures with clean interfaces. I will also discuss in detail their subsequent patterning into functional devices along with interface characterisation. The work presented has been carried out in Minalab, Nanolab and NorTem facilities.