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L-DOPA-Coated Manganese Oxide Nanoparticles as Dual MRI Contrast Agents and Drug-Delivery Vehicles

Abstract

Manganese oxide nanoparticles (MONPs) are capable of time-dependent magnetic resonance imaging contrast switching as well as releasing a surface-bound drug. MONPs give T2/T2* contrast, but dissolve and release T1-active Mn2+ and L-3,4-dihydroxyphenylalanine. Complementary images are acquired with a single contrast agent, and applications toward Parkinson's disease are suggested.
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Category

Academic article

Language

English

Author(s)

  • Birgitte Hjelmeland McDonagh
  • Gurvinder Singh
  • Sjoerd Hak
  • Sulalit Bandyopadhyay
  • Ingrid Lovise Augestad
  • Davide Peddis
  • Ioanna Sandvig
  • Axel Sandvig
  • Wilhelm R Glomm

Affiliation

  • SINTEF Industry / Biotechnology and Nanomedicine
  • Umeå University
  • National Research Council
  • University of Cambridge
  • Norwegian University of Science and Technology

Year

2016

Published in

Small

ISSN

1613-6810

Volume

12

Issue

3

Page(s)

301 - 306

View this publication at Norwegian Research Information Repository