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Sample metering and parallel liquid plug actuation for multiple biochemical assays

Abstract

We demonstrate a passive microfluidic system for simple and efficient metering, handling and control of parallel nanoliter samples on-chip.  The system consist of two chips; one for sample loading, splitting and metering (based on capillary forces only), and another for sample plug movement in parallel reaction channels.  The latter is based on a set of capillary valves and one single external pressure source only.  The strength of the capillary valves determines the logic movement of the parallel sample droplets on-chip, permitting robust system control.  In general, the presented system is applicable to a variety of multi-step reaction protocols with a large number of parallel channels.

Category

Academic lecture

Language

English

Affiliation

  • SINTEF Digital / Microsystems and Nanotechnology

Presented at

MicroTAS 2007

Place

Paris, Frankrike

Date

08.10.2007 - 11.10.2007

Organizer

The Chemical and Biological Microsystems Society

Year

2007

External resources

View this publication at Cristin