In this work, a dynamic model of the Brindisi CO2 capture pilot plant is implemented in K-spice general simulation tool. The model is used to simulate relevant step changes performed during a pilot plant campaign conducted in the EU project Octavius in May and June 2013. Model results are compared to dynamic pilot plant data and it shows good transient agreement to the experimental results. The model is therefore able to capture the main process dynamics. An offset is, however, observed in some cases, especially during the initial simulation time. This is most likely caused by the fact that the model was given a steady state starting point, while the pilot plant was not necessarily completely at steady state when the step change was introduced. It is challenging to ensure steady state conditions prior to dynamic tests in a pilot plant, especially for one that is connected to a real power production unit as this one. Power production variations will act as disturbances to the capture unit, and due to slow transients in the solvent inventory of the capture unit, it will take several hours to ensure steady state conditions with stable inlet flue gas conditions.