Abstract
The blood-brain barrier (BBB) is hypothesized to play a role in the pathophysiology of psychosis. However, studying this structure in living humans is challenging due to limitations in current methods that fail to identify subtle changes or dysfunctions. We aimed to develop a method to isolate extracellular vesicles (EVs) in peripheral blood derived from the blood-brain barrier (BBB), offering a “liquid biopsy of the BBB”. We proposed that analyzing the content of these EVs would provide novel insights into BBB activity and signaling in humans, and launch potential biomarkers for neuropsychiatric conditions.