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Well-posedness of a model equation for neurotransmitter diffusion with reactive boundaries

Sammendrag

We consider a diffusion equation with reactive boundary conditions. The equation is a model equation for the diffusion of classical neurotransmitters in the tortuous space between cells in the brain. The equation determines the concentration of neurotransmitters such as glutamate and GABA (gamma-aminobutyrate) and the probability for neurotransmitter molecules to be immobilized by binding to protein molecules (receptors and transporters) at the cell boundary (cell membrane). On a regularized problem, we derive a priori estimates. Then, by a compactness argument, we show the existence of solutions. By exploiting the particular structure of the boundary reaction terms, we are able to prove that the solutions are unique and continuous with respect to initial data.

Kategori

Vitenskapelig artikkel

Språk

Engelsk

Forfatter(e)

  • Xavier Raynaud
  • Magne André Nordaas
  • Knut Petter Dæhlin Lehre
  • Niels Christian Danbolt

Institusjon(er)

  • Norges teknisk-naturvitenskapelige universitet
  • SINTEF Digital / Mathematics and Cybernetics
  • Simula Research Laboratory
  • Universitetet i Oslo

År

2015

Publisert i

Mathematical Models and Methods in Applied Sciences

ISSN

0218-2025

Forlag

World Scientific

Årgang

25

Hefte nr.

2

Side(r)

195 - 227

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