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Håvard Sletta

Forskningsleder

Håvard Sletta

Forskningsleder

Håvard Sletta
Telefon: 915 44 429
Mobil: 915 44 429
Avdeling: Bioteknologi og nanomedisin
Kontorsted: Trondheim

Publikasjoner og ansvarsområder

Publikasjoner

Publikasjon

New Deferoxamine Glycoconjugates Produced upon Overexpression of Pathway-Specific Regulatory Gene in the Marine Sponge-Derived Streptomyces albus PVA94-07

http://www.sintef.no/publikasjoner/publikasjon/?pubid=CRIStin+1453097

Activation of silent biosynthetic gene clusters in Streptomyces bacteria via overexpression of cluster-specific regulatory genes is a promising strategy for the discovery of novel bioactive secondary metabolites. This approach was used in an attempt to activate a cryptic gene cluster in a marine spo...

Forfattere Sekurova Olga Pérez-Victoria Ignacio Martin Jesús Degnes Kristin Fløgstad Sletta Håvard Reyes Fernando Zotchev Sergey
År 2016
Type Tidsskriftsartikkel
Publikasjon

Fluxome study of Pseudomonas fluorescens reveals major reorganisation of carbon flux through central metabolic pathways in response to inactivation of the anti-sigma factor MucA

http://www.sintef.no/publikasjoner/publikasjon/?pubid=CRIStin+1234847

The bacterium Pseudomonas fluorescens switches to an alginate-producing phenotype when the pleiotropic anti-sigma factor MucA is inactivated. The inactivation is accompanied by an increased biomass yield on carbon sources when grown under nitrogen-limited chemostat conditions. A previous metabolome ...

Forfattere Lien Stina Katrine Niedenführ Sebastian Sletta Håvard Nöh Katharina Bruheim Per
År 2015
Type Tidsskriftsartikkel
Publikasjon

The effect of the carbohydrate binding module on substrate degradation by the human chitotriosidase

http://www.sintef.no/publikasjoner/publikasjon/?pubid=CRIStin+1265324

Human chitotriosidase (HCHT) is one of two active glycoside hydrolase family 18 chitinases produced by humans. The enzyme is associated with several diseases and is thought to play a role in the anti-parasite responses of the innate immune system. HCHT occurs in two isoforms, one 50 kDa (HCHT50) and...

Forfattere Stockinger Linn Wilhelmsen Eide Kristine Bistrup Dybvik Anette Israelsen Sletta Håvard Vårum Kjell Morten Eijsink Vincent Tøndervik Anne Sørlie Morten
År 2015
Type Tidsskriftsartikkel
Publikasjon

Anti-microbial and cytotoxic 1,6-dihydroxyphenazine-5,10-dioxide (iodinin) produced by Streptosporangium sp. DSM 45942 isolated from the fjord sediment

http://www.sintef.no/publikasjoner/publikasjon/?pubid=CRIStin+1061610

Phenazine natural products/compounds possess a range of biological activities, including anti-microbial and cytotoxic, making them valuable starting materials for drug development in several therapeutic areas. These compounds are biosynthesized almost exclusively by eubacteria of both terrestrial an...

Forfattere Sletta Håvard Degnes Kristin Fløgstad Herfindal Lars Klinkenberg Geir Fjærvik Espen Zahlsen Kolbjørn Brunsvik Anders Nygaard Gyrid Aachmann Finn Lillelund Ellingsen Trond Erling Doskeland Stein Ove Zotchev Sergey
År 2014
Type Tidsskriftsartikkel
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